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. 2019 Jul 1;9:9488. doi: 10.1038/s41598-019-45892-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Activity Ratio (AR) scores of the input molecules of (A) aNSC (B) GSC and (C) GBM Model simulations. The AR-scores of each input molecules were calculated for every cellular state. TP53 protein was found as mutated in the “GSC Model” simulation. On the other hand, while simulating “GBM Model”, TP53 protein was found mutated along with increased activities of RBPJ+/+, JAK2+/+ and STAT3+/+ proteins.