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. 2019 Jul 1;9:9488. doi: 10.1038/s41598-019-45892-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Stage transition graph (STG) of the development of distinct sub-types of GBM. The Red and blue nodes represent the initial and transient cellular states of the general glioma developmental model. It shows that starting from a group of common tumor-initiating cells (red colored nodes), the tumorigenic developmental process leads towards distinct grades (sub-types) and heterogeneity in the GBM tumor cells. ASPC and ASPC/GSC refer the cyclic attractor states “ASPC Differentiation or LGG-I” and “GSC Renewal/ASPC Differentiation or LGG-II” respectively, whereas GBM refers the cellular state corresponding to “GSC Renewal/ASPC Differentiation/GBM Development or Grade-IV” cellular state.