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. 2019 Jul 1;10:2898. doi: 10.1038/s41467-019-10899-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Molecular models predict that DH753 and DH727.2 interact with trimeric HIV-1 Env in the open conformation. a–d Docking DH727.2 and DH753 onto to a single gp120 from a closed envelope trimer (PDB: 4ZMJ, https://www.rcsb.org/structure/4ZMJ) indicates clashes, marked by arrows where the polypeptide chains overlap (a,b); whereas docking onto a CD4-induced, open gp120 monomer (PDB: 5VN3 https://www.rcsb.org/structure/5VN3) does not show any clashes (c, d). e–h The open trimer can accommodate three copies of either Fab, as shown in the side view (e, f) and top view (g, h). Colors are the same as in Figure 5, red/salmon indicate DH727.2, lilac/purple represent DH753, yellow shows the distal end of the V3 loop (residues 301-323), and gray depicts gp120/gp41. The scale is equal in all images