Table 3.
Comparison of observed allele frequencies and genotype distributions in the PCOS and control groups, testing for Hardy-Weinberg equilibrium in the PCOS and control groups (HWEp value: p value for Hardy-Weinberg equilibrium; PCOS vs. control group p value: p value for comparison of allele and genotype distributions between PCOS and control groups)
| Polymorphism (allele/genotype) | Control (n (%)) | PCOS (n (%)) | PCOS vs. control group p value |
|---|---|---|---|
| N | 23 | 75 | |
| AMH rs10407022 | |||
| G:T | 24 (52.2):22 (47.8) | 80 (53.3):70 (46.7) | > 0.999 |
| GG:TG:TT | 8 (34.8):8 (34.8):7 (30.4) | 22 (29.3):36 (48.0):17 (22.7) | 0.525 |
| HWEp value | 0.491 | 0.969 | |
| AMHR2 rs2002555 | |||
| A:G | 39 (84.8):7 (15.2) | 124 (82.7):26 (17.3) | 0.912 |
| AA:AG:GG | 17 (73.9):5 (21.7):1 (4.3) | 52 (69.3):20 (26.7):3 (4.0) | 0.908 |
| HWEp value | 0.850 | 0.893 | |
| Fok1 rs2228570 | |||
| C:T | 35 (76.1):11 (23.9) | 117 (78.0):33 (22.0) | 0.944 |
| CC:CT:TT | 13 (56.5):9 (39.1):1 (4.3) | 48 (64.0):21 (28.0):6 (8.0) | 0.631 |
| HWEp value | 0.956 | 0.461 | |
| Bsml rs1544410 | |||
| A:G | 19 (41.3):27 (58.7) | 52 (34.7):98 (65.3) | 0.520 |
| AA:GA:GG | 4 (17.4):11 (47.8):8 (34.8) | 8 (10.7):36 (48.0):31 (41.3) | 0.633 |
| HWEp value | 0.999 | 0.914 | |
| Apal rs7975232 | |||
| A:C | 35 (76.1):11 (23.9) | 109 (72.7):41 (27.3) | 0.788 |
| AA:CA:CC | 13 (56.5):9 (39.1):1 (4.3) | 37 (49.3):35 (46.7):3 (4.0) | 0.840 |
| HWEp value | 0.956 | 0.440 | |
| Cdx2 rs11568820 | |||
| A:G | 14 (30.4):32 (69.6) | 30 (20.0):120 (80.0) | 0.200 |
| *AA:GA:GG | 1 (4.3):12 (52.2):10 (43.5) | 7 (9.3):16 (21.3):52 (69.3) | 0.018 |
| HWEp value | 0.641 | 0.096 | |
*The results in italics are statistically significant