Table 3.
Comparison ovarian response-related parameters, laboratory results, and clinical outcomes between NOR and DOR group
| Parameters | NOR (n = 118) | DOR (n = 46) | P value |
|---|---|---|---|
| GN day (day) | 11 (9–12) | 7 (5–10) | < 0.0001 |
| Total GN dosage (IU) | 1650 (1293.75–2200) | 1200 (750–2569) | < 0.05 |
| OPU egg number | 14 (9–19) | 3 (1–4) | < 0.001 |
| 2pn number | 8 (5–12.25) | 1 (0.25–1.00) | < 0.001 |
| Fertilization rate | 68.42 (57.14–82.79) | 75.00 (25.00–100.00) | ns |
| 2pn cleavage number | 8 (5–12) | 1 (1–3) | < 0.001 |
| 2pn cleavage rate (%) | 90.00 (75.74–100.00) | 79.17 (18.75–100.00) | ns |
| D3 embryo number | 6 (3–10) | 1 (0–2) | < 0.001 |
| D3 good embryo number | 5 (2.75–8) | 1 (0–1.25) | < 0.001 |
| D3 good embryo rate (%) | 67.54 (50.00–83.99) | 33.33 (0.00–100.00) | < 0.001 |
| Culture D3 embryo number | 6 (4–9) | 2 (1–3) | < 0.05 |
| Blastocyst number | 3 (2–6) | 1 (0–2) | ns |
| Good blastocyst number | 2 (1–6) | 0 (0–1.75) | ns |
| Blastocyst formation rate (%) | 55.56 (33.33–75.00) | 41.67 (0–65.91) | ns |
| Frozen embryo number | 3 (1.75–7) | 0 (0–1) | < 0.0001 |
| Embryo transfer n (%) | 106 (89.83) | 22 (48.89) | < 0.0001 |
| Embryo implantation n (%) | 102 (51.51) | 13 (30.23) | ns |
| Clinical pregnancy n (%) | 56 (52.83) | 6 (27.27) | < 0.0001 |
| Live birth n (%) | 45 (42.45) | 6 (27.27) | < 0.0001 |
All parameters were shown as median (interquartile range (IQR) and were compared using Mann-Whitney U test. The numerical data were expressed as n (%) and were compared using Chi-square test or Fisher’s exact test. A difference with P < 0.05 (two-sided) was considered statistically significant
GN day gonadotrophin usage day, total GN dosage total dose of gonadotrophin, OPU egg number number of oocytes retrieved