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. 2019 Jan 17;236(6):1771–1782. doi: 10.1007/s00213-018-5162-7

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — SCH23390 impairment of contextual fear conditioning is not accounted for by state dependency. a Schematic representation of the experimental design used. b SCH23390 injection before conditioning (SCH-VEH and SCH-SCH) increased freezing before and after shock presentations, compared to vehicle (VEH-VEH and VEH-SCH) (P < 0.05). c There was no difference in freezing between the VEH-VEH and VEH-SCH groups throughout retrieval, whereas freezing in the SCH-VEH and SCH-SCH groups was decreased, compared to the VEH-VEH and VEH-SCH groups (*P < 0.05). d The time course analysis of freezing during retrieval also showed that freezing in the SCH-VEH and SCH-SCH groups was decreased, compared to the VEH-VEH and VEH-SCH groups (*P < 0.05)