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. 2019 Jul 1;9:9485. doi: 10.1038/s41598-019-45538-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between chromosomal copy number variations and gene expression levels in the SSG_S and SSG_R lines of L. braziliensis and L. panamensis. The heatmaps show median normalized read depths of 35 chromosomes (y axis) found in L. braziiensis (Left) and L. panamensis (right) sensitive and resistant to Sb^III (x axis) The color key indicates the somy value (S), which ranged from 1 to 5 as follows: monosomy, S < 1.5; disomy, 1.5 ≤ S < 2.5; trisomy, 2.5 ≤ S < 3.5; tetrasomy, 3.5 ≤ S < 4.5; and pentasomy, 4.5 ≤ S < 5⁴⁰. A black triangle in an upper right corner indicates a significant change in S value. R (replicates).