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. 2019 Jul 1;9:9423. doi: 10.1038/s41598-019-45962-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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S. aureus H₂O₂ tolerance upon sub-lethal aBL/aPDI and CIP treatment. The MIC of H₂O₂ was determined using the broth microdilution method for the 1^st, 5^th, 10^th and 15^th cycle isolates according to the EUCAST guidelines. Moreover, the time-dependent toxicity of 4% H₂O₂ was examined. To assess the survival rates, aliquots were taken at 0, 5, 10, 20, 30 and 60 min after the administration of H₂O₂ and spread on TSB agar plates to determine the CFU. Hydrogen peroxide MIC was presented at panel A and time-dependent cytotoxicity at panel B. The values are the means of three separate experiments. Error bars represent standard deviation (SD). ^a - statistically significant difference from day 1 (P = 0.00023), day 10 and day 15 (both P = 0.00017), ^b - statistically significant difference from day 1 and day 5 (both P = 0.00017), ^c - statistically significant difference from day 1 and day 5 (both P = 0.00017).