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. 2019 Jul 1;9:9468. doi: 10.1038/s41598-019-45990-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison between quantitative and visual analysis of low-dose thin section volumetric lung CT in a SSc patient without visual evidence of ILD but a CII lower than the cut-off value of 0.1966 (e. g. CII = −0.3718). On the left, the figure shows the results from digital processing analysis: in the upper-left side of the image, data from the analysis of a single representative slice are given; in the lower-left side of the image the automatically generated averaged data from the analysis of all slices are given. Global pulmonary sampling has been performed and the sampled region is marked in yellow. CT = computed tomography; SSc = systemic sclerosis; ILD = interstitial lung disease; CII = computerized integrated index.