Table 2.
Lung function assessment in the SSc patients at baseline.
| Parameter | All patients (n = 83) | ILD+ (n = 39) | ILD− (n = 44) | p* |
|---|---|---|---|---|
| Arterial pO2 (mmHg) at rest (21% FiO2) | 83.7 ± 11.8 | 83 ± 2.2 | 84.2 ± 1.8 | 0.6 |
| Arterial SpO2 (%) (median, range) | 98.2 (83.5–100) | 97.9 (83.5–99.5) | 98.3 (95.3–100) | 0.37 |
| FVC (% predicted) | 99.7 ± 25 | 89.2 ± 26.0 | 107.8 ± 21.2 | 0.001 |
| TLC (% predicted) | 80.9 ± 18.2 | 75.4 ± 20.9 | 85.6 ± 14.1 | 0.021 |
| RV (% predicted) | 78.5 ± 26.7 | 61.7 ± 3.6 | 91.7 ± 4.3 | <0.001 |
| DLCOsb (% predicted) | 59 ± 19.4 | 51.2 ± 18.9 | 65.4 ± 17.5 | 0.001 |
| 6MWT distance (mt) (median, range) | 440 (176–566) | 426 (264–528) | 462 (176–566) | 0.24 |
| 6MWT ΔSpO2 (%) (median, range) | 2 (0–18) | 3 (0–18) | 1 (0–14) | 0.002 |
Data are expressed as mean ± standard deviation, except where otherwise indicated.
SSc = systemic sclerosis; ILD = interstitial lung disease; pO2 = oxygen partial pressure; FiO2 = fraction of inhaled oxygen; SpO2 = oxygen saturation; FVC = forced vital capacity; TLC = total lung capacity; RV = residual volume; DLCOsb = single breath diffusion lung capacity for carbon monoxide; 6MWT = six-minute walk test; mt = meters.
*p is ILD+ versus ILD−.