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. 2019 Jul 1;9:9437. doi: 10.1038/s41598-019-46019-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of iron-related genes in WT, Heph KO, and Cp KO OPCs. (A) Representative image of WT OPCs stained with the OPC marker A2B5 (red) and DAPI (blue) to show the nuclei. (B–F) Fpn1(+IRE) (B), L-ferritin (C), H-ferritin (D), Tfrc (E) and Dmt1(+IRE) (F) mRNA levels in WT, Heph KO, and Cp KO OPCs. Expression in WT OLs is also shown. Data are representative of at least three independent experiments. OPC: oligodendrocyte precursor cell, OL: oligodendrocyte; UD: undetectable; NS: not significant vs WT OPCs; values are presented as the means ± SEMs; *P < 0.05, different from WT OLs, as determined by unpaired Student’s t-test.