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(A) The difference in time spent in the center of the open field, before and after the ISS, predicted subsequent demand for heroin. (B) Increased climbing during the 5 min of FST, administered the day after ISS, predicted subsequent demand for heroin. (C) Together, open field difference score and forced swim climbing (visualized as predicted values from a linear model) explain 72% of the variance (R2) in subsequent demand for heroin.
