Fig. 4.

BMP15 induces the downstream effectors of FSHR. a The HGrC1 cells were treated with or without 500 ng/ml BMP15 or 5 IU/ml human recombinant FSH for 48 h, after 10 μM androstenedione was added in the culture medium. The HGrC1 cells were stimulated, after 10 μM androstenedione was added in the culture medium. BMP15 increased CYP19A1 mRNA expression, while increase with FSH was minimal. Additive effects of BMP15 and FSH were observed. b BMP15 increased estradiol production. All data are shown as mean ± SD of three experiments. **p < 0.001 vs. control