Table 1.

Summary of the developmental neurobehavioral response to threat to a across development after experiencing infant trauma.

	PN18 late infancy	PN45 adolescence	>PN75 adults
Behavioral response to threat	Increased	Decreased	Increased
	Integrating our adolescent neural results with existing literature
Amygdala	Increased	Decreased	Increased
PFC PL	NA	Increased	Increased

Infants experienced PN8-12 maternal maltreatment with Scarcity-Adversity LB Model induced by providing mothers with insufficient bedding for nest building. Summarizing the behavioral data presented here, maltreatment produced a decrease response to threat while this same procedure produced a development switch to a maltreatment induced decrease followed by a developmental switch to adult increase. Next we integrate our adolescent amygdala and PL results with the existing literature on infants (Bath, 2018; Santiago et al., 2018; Opendak et al., 2019) and extensive adult literature (Barbosa Neto et al., 2012; Dannlowski et al., 2013; Jovanovic et al., 2014; Hartley and Lee, 2015; van Rooij et al., 2017; Demers et al., 2018; Norrholm and Jovanovic, 2018). Overall, the amygdala activity tracks trauma-induced changes in threat expression across the lifespan, while the PL does not.