Table 3.
Difference in base sequence and resulting amino acid sequence of feline adenovirus fiber protein as compared to analogous human adenovirus (HAdV) type 1 nucleotides and proteins.
| Base # | Feline base | D11 human base | ATCC AB125750 base | Amino acid # | Location | Feline amino acid (charge) | D11 human amino acid (charge) | ATCC 125750 amino acid |
|---|---|---|---|---|---|---|---|---|
| Shaft portion (amino acids 45–401) | ||||||||
| 220 | A | G | A | 74 | 2. pseudorepeat | Lysine (+) | Glutamic acid (-) | Lysine (+) |
| 596 | A | G | A | 199 | 9. pseudorepeat | Asparagine | Serine | Asparagine |
| 981 (1047∗) | A | A | G | 327 | 17. pseudorepeat | Lysine (+) | Lysine (+) | Lysine (+) |
| 1015 | C | A | C | 339 | 18. pseudorepeat | Histidine (+) | Asparagine | Histidine (+) |
| Knob portion (amino acids 402–582) | ||||||||
| 1240 | C | T | C | 414 | AB loop | Histidine (+) | Tyrosine | Histidine (+) |
| 1248 | C | T | C | 428 | BC loop | Cysteine | Cysteine | Cysteine |
| 1325 | G | A | G | 442 | CD loop | Arginine (+) | Lysine (+) | Arginine (+) |
| 1341 | T | C | T | 447 | CD loop | Proline | Proline | Proline |
| 1395 | A | G | A | 465 | DE loop | Glycine | Glycine | Glycine |
| 1414 | A | G | A | 472 | DE loop | Serine | Glycine | Serine |
| 1581 | A | T | A | 527 | GH loop | Glutamic acid (-) | Aspartic acid (-) | Glutamic acid (-) |
| 1659 | C | A | A | 553 | HI loop | Serine | Serine | Serine |
| 1743 | G | A | A | 581 | Carboxy terminal | Glutamine | Glutamine | Glutamine |
∗Nucleotide number of AB125750 published in ATCC. Silent amino acid alterations as compared to the feline amino acids are shown in italic.