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. 2019 Jun 25;10:1432. doi: 10.3389/fimmu.2019.01432

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Copyright © 2019 Yu, Liu, Tang, Xu, Ouyang and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MLN4924 suppresses the expression of IFN and ISGs in ZFL cells after poly (I:C) stimulation. (A–I) Treatment of ZFL cells with 1 μM MLN4924 after poly(I:C) stimulation downregulated ifn1 (A), ifn2 (B), rsad (C), mxb (D), mxc (E), pkz (F), mavs (G), rig1 (H), tlr3 (I). Additions of the same amount of DMSO were used as controls. Data are shown as mean ± SEM of three independent experiments, each performed in triplicate; the statistical analysis was performed using GraphPad Prism 5 (unpaired t-test).