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. 2019 Jun 25;10:1432. doi: 10.3389/fimmu.2019.01432

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Copyright © 2019 Yu, Liu, Tang, Xu, Ouyang and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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nedd8-null adult zebrafish are more sensitive to SVCV infection than WT zebrafish. (A,B) nedd8-null zebrafish (3 mpf; 0.38 ± 0.02 g) and the WT (3 mpf; 0.38 ± 0.02 g) were each i.p. injected with 10 μL SVCV (~2 × 10⁸ TCID₅₀/ml) at 0 day. (C,D) At 1 day post-injection (dpi), there were no obvious differences between the WT (nedd8^+/+) and nedd8-null zebrafish (nedd8^−/−). (E,F) At 2 dpi, the WT zebrafish appeared normal, but the nedd8-null zebrafish had more swelling and hemorrhagic symptoms in the abdomen (indicated by red arrows).