Table 2.

Asthma presentations across the lifecourse.

Age	Presentation/Phenotype	Description
Child	Asthma diagnosis	Physician's diagnosis of asthma at least once per lifetime or recurrent diagnoses of spastic, obstructive, or asthmatic bronchitis as reported by the parents at age 6 years
	Frequent wheeze	Wheeze on a monthly basis for at least 1 year between age 1 and 6 years
	Unremitting wheeze	Having symptoms between wheezing episodes or having wheeze without a cold at least once between age 1 and 6 years
	Recurrent unremitting wheeze	Having symptoms between wheezing episodes or wheeze without a cold for 2 or more years between age 1 and 6 years
	Multi-Trigger wheeze	Having at least 2 common asthma triggers leading to wheeze between ages 3 and 6 years
	Episodic wheeze	Wheezing episodes associated only with viral upper respiratory infection between age 1 and 6 years.
	Severe asthma Difficult to control asthma Therapy resistant asthma	Asthma which is poorly controlled based on frequent symptoms and significant morbidity Often due to incorrect diagnosis, poor adherence to therapy, incorrect inhaler/spacer technique, uncontrolled comorbidities (allergic rhinitis) Poorly controlled asthma after ruling out “Difficult to control asthma”
	Eosinophilic predominant asthma	Allergic asthma
	Neutrophilic predominant asthma	Non-allergic asthma
	Recurrent croup	Repeated episodes of croup
	Middle lobe syndrome	Repeated episodes of middle lobe infiltrate or atelectasis
	Recurrent pneumonia	Repeated episodes of lung infection
Adult	Late onset eosinophilic asthma	Later onset, predominately female, and elevated sputum and serum eosinophils, associated with sinusitis
	Obesity related asthma	Associated with increased levels of TNFa, IL-6, leptins, less eosinophils, FeNO, and corticosteroid responsiveness
	Neutrophilic asthma	Difficult to characterize, often severely obstructed with only partial reversibility and a high healthcare utilization
	Aspirin- associated asthma	Subset of late-onset eosinophilic asthma, associated with sinusitis, nasal polyps, and sensitivity to cyclooxygenase-1 inhibitors
	Allergic bronchopulmonary aspergillosis	Lower airway allergic sensitization to Aspergillus fumigatus causing asthma exacerbations, pulmonary function deterioration, mucous plugging, central bronchiectasis, and transient pulmonary infiltrate