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. 2019 Jul 1;9:9491. doi: 10.1038/s41598-019-45570-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Diagnostic accuracy in early stage versus late stage and proximal versus distal colorectal cancer. (A) Summary receiver operating characteristic curves (SROC) for early (n = 11) and late (n = 11) stage CRC. (B) SROC for proximal (n = 9) and distal (n = 9) CRC. The number next to the blue dot/red triangle corresponds to the study ID in Table 1. The circular regions (95% confidence contour) contain likely combinations of the mean value of sensitivity and specificity. Sen = sensitivity; Spe = specificity SOP, summary operating point. ^#Early stage CRC includes TMN stages 0 + I + II or Dukes’ stage A + B; late stage CRC includes CRC stages III + IV or Dukes’ stage C + D. Proximal CRC is defined as from cecum to transverse colon, and distal CRC is defined as from the splenic flexure to the rectum.