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. 2019 Jul 1;9:9482. doi: 10.1038/s41598-019-45890-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Combined PC945 and posaconazole treatment within an in vitro model of the human alveolus. (A) Time course comparison of compounds alone or combined against azole-susceptible A. fumigatus (NCPF2010) penetration of the bilayer, vehicle infection control (●), PC945 (0.1 μg/mL, upper, ■), posaconazole (0.01 μg/ml, lower, Δ), combination (○). n = 3 (B–E) Representative images of histological analysis of A. fumigatus (NCPF2010) infected bilayer, with mono- or combined compound administration, [haematoxylin & eosin staining (x400)], (B) A. fumigatus infection control, (C) posaconazole (0.01 μg/ml, lower), (D) PC945 (0.1 μg/ml, upper) and (E) combined. Arrows: fugal body, (F) Time course comparison of compounds alone or in combination against azole-resistant A. fumigatus (TR₃₄/L98H) penetration of the bilayer, vehicle infection control (●), PC945 (1 μg/mL, upper, ■), posaconazole (0.1 μg/ml, lower, Δ), combined (○). n = 3 *p < 0.05, **p < 0.01, ***p < 0.001 vs. control.