Table 5.
Association between location of SVD and ePVS (EDIS study).
| SVD markers | Total ePVS RR (95% CI) | Centrum semiovale ePVS RR (95% CI) | Basal ganglia ePVS RR (95% CI) |
|---|---|---|---|
| Total CMBs | 1.00 (0.99, 1.01) | 0.99 (0.98, 1.00) | 1.00 (0.99, 1.01) |
| Strictly lobar CMBs | 0.98 (0.83, 1.16) | 0.92 (0.78, 1.10) | 1.10 (0.92, 1.32) |
| Strictly deep CMBs | 1.22 (0.84, 1.77) | 1.27 (0.86, 1.88) | 0.88 (0.57, 1.35) |
| Mixed CMBs | 1.00 (0.99, 1.01) | 0.99 (0.98, 1.00) | 1.00 (0.99, 1.01) |
| Strictly lobar lacunes | 1.12 (0.88, 1.42) | 1.04 (0.80, 1.36) | 1.27 (1.00, 1.62) |
| Strictly deep lacunes | 1.23 (0.86, 1.75) | 1.21 (0.83, 1.77) | 1.25 (0.85, 1.83) |
| Mixed lacunes | 1.00 (0.86, 1.16) | 0.78 (0.63, 0.94) | 1.16 (0.99, 1.36) |
| Anterior WMH volume | 1.00 (0.99, 1.01) | 1.00 (0.99, 1.01) | 1.01 (0.99, 1.02) |
| Posterior WMH volume | 1.00 (0.99, 1.01) | 1.00 (0.99, 1.01) | 1.00 (0.99, 1.01) |
RR, rate ratio; CI, confidence interval; CMBs, cerebral microbleeds; ePVS, enlarged perivascular spaces; WMH, white matter hyperintensity; EDIS, Epidemiology of Dementia in Singapore. All values adjusted for age, gender, hypertension, hyperlipidemia, and diabetes.