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Representative neuropathological cases. (A) Transverse semi-thin sections of motor nerve biopsy (obturator nerve), and sural sensory nerve biopsy (B) from a patients with MND. (A) Focal loss of myelinated nerve fibers is evident (asterisk) in the endoneurium together with signs of acute axonal degeneration (myelin ovoids, arrows); no signs of regeneration are observed. (B) In sural sensory nerve biopsies a diffuse mild reduction of large nerve fibers is observed. Bar: 20 μm.
