Tail veins of STZ-induced model rats (n=30 and 5 mice died or were not successfully modeled during STZ induction) were injected with liposomes containing different sequences (miR-15a-5p mimic, miR-15a-5p inhibitor or FASN shRNA) three times a week for 4 weeks. After 4 weeks, whole blood is used to isolate serum (n=6 for each group) and HDL-C, LDL-C and TC were quantitated by ELISA. Data shown are mean ± SD, experiments had been repeated three times; *, P<0.05 compared with NC group; @, P<0.05 compared with miR-15a-5p mimic + sh-FASN group.