Tail veins of STZ-induced model rats (n=30 and 5 mice died or were not successfully modeled during STZ induction) were injected with liposomes containing different sequences (miR-15a-5p mimic, miR-15a-5p inhibitor or FASN shRNA) three times a week for 4 weeks. After 4 weeks, the thoracic aortas of each group rats (n=6 for each group) was isolated and used for Oil Red O staining. (A) Staining image of Oil Red O staining; (B) area percentage of fatty streaks. Data shown are mean ± SD, experiments had been repeated three times, *, P<0.05 compared with NC group; @, P<0.05 compared with miR-15a-5p mimic + sh-FASN group.