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. 2019 Jul 1;7(13):e14149. doi: 10.14814/phy2.14149

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© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Relationships between the z‐scores of alveolar membrane diffusive conductance for CO (DM_CO) (y‐axis) and pulmonary capillary blood volume (V_C) (x‐axis) in mild hyperoxia (left panel) and normoxia (right panel) in healthy controls (asterisks) and SSc subjects. Symbols indicate subjects with spirometry and total lung capacity (TLC) > LLN₅ (white), DL_CO < LLN₅ (light grey), and TLC < LLN₅ (dark grey). Triangles indicate subjects with systolic pulmonary artery pressure (sPap) > 36 mmHg. The dashed lines indicate the LLN₅ (z‐score < −1.645). The absolute values indicate the number of the total 96 test results for DM_CO that fall into each quadrant (Q1–Q4).