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. 2019 Jul 1;7(13):e14149. doi: 10.14814/phy2.14149

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© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Correlations between mean lung density (g·mL⁻¹) or fibrosis extent (% CT volume) and z‐scores of (A) forced vital capacity (FVC) and (B) TLC. Symbols indicate SSc subjects with spirometry and TLC > LLN₅ (white), DL_CO < LLN₅ (light grey), and TLC < LLN₅ (dark grey) with (n = 11) or without (n = 3) DL_CO < LLN₅. Triangles indicate subjects with sPap > 36 mmHg. CI_95% of the best‐fit regression line is marked by dotted lines whereas horizontal dashed line indicates the 5^th percentile of reference values (−1.645 z‐score).