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. 2019 Jun 27;14:4649–4666. doi: 10.2147/IJN.S201110

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© 2019 Xu et al.

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(A) TEM images of HA(HECS-ss-OA)/GA (a) and HA(HECS-cc-OA)/GA (b) nanoparticles after 4-hr incubation with 10 mM DTT in pH 7.4 HEPES. Scar bar is 500 nm. (B) Fluorescence spectra of HA(HECS-ss-OA)/NR (a) and HA(HECS-cc-OA)/NR (b) nanoparticles in pH 7.4 HEPES solution supplemented with 10 mM DTT at the excitation wavelength of 326 nm for different times. (C) Size change of HA(HECS-ss-OA)/GA (a) and HA(HECS-cc-OA)/GA (b) nanoparticles in response to DTT determined by DLS measurement.

Abbreviations: TEM, transmission electron microscopy; HA, hyaluronic acid; HECS, hydroxyethyl chitosan; OA, octylamine; GA, gambogic acid; DTT, dithiothreitol; HEPES, 2-[4-(2-Hydroxyethyl)-1-piperazinyl] ethanesulfonic acid; NR, Nile red; DLS, dynamic light scattering.