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Tumor growth (A) and tumor weight (B) of A549 tumor-bearing mice administrated with saline, GA, HECS-ss-OA/GA, HA(HECS-ss-OA)/GA and HA(HECS-cc-OA)/GA at a GA dose of 8 mg/kg. Data are represented as the mean ± SD (n = 5). ***P < 0.001; **P < 0.01; *P <0.05. (C) Images of H&E-stained (a) and TUNEL-stained (b) tumor sections, scale bar is 200 μm.
Abbreviations: HA, hyaluronic acid; HECS, hydroxyethyl chitosan; OA, octylamine; GA, gambogic acid.
