Table 4.
Clusters of voxels that differ between healthy control, surgery and radiation groups.
| Contrast | Cluster (number of voxels) | Cluster Family-Wise Error Corrected p | WM structuresa encompassed | Mean T value |
|---|---|---|---|---|
| FA | ||||
| Radiation < control | 11,270 | < 0.01 | Forceps minor, CST, forceps major, SLF, cingulum (cingulate gyrus), IFOF, ATR, ILF, UF (L), SLF (temporal part), cingulum (hippocampus) | 2.02 |
| 3094 | 0.01 | ATR, IFOF, ILF, CST (L), SLF (L), UF (L), SLF (temporal part), forceps minor, cingulum (cingulate gyrus) (R) | 2.63 | |
| 784 | 0.04 | Forceps minor, ATR (L), IFOF (L), cingulum (cingulate gyrus) (L), UF (L), SLF (L), SLF (temporal part) (L) | 1.74 | |
| 748 | 0.02 | CST (R), ATR (R) | 3.56 | |
| 743 | 0.02 | ATR (L), CST | 3.91 | |
| Radiation < surgery | 0 | – | – | – |
| Surgery < control | 12,722 | 0.01 | IFOF, ILF, SLF, forceps major and minor, CST, SLF (temporal part), cingulum (cingulate gyrus), ATR, cingulum (hippocampus), UF | 1.9 |
| 5197 | 0.02 | ATR, CST, IFOF, ILF, UF (L), SLF, SLF (temporal part), forceps minor, cingulum (hippocampus) (L), cingulum (cingulate gyrus) (R) | 2 | |
| 2425 | 0.03 | ATR, CST | 2.15 | |
| 1575 | 0.04 | IFOF (L), forceps major, ILF (L), SLF (L), SLF (temporal part) (L), ATR, cingulum (hippocampus) (L) | 2.05 | |
| Control < radiation | 0 | – | – | – |
| Surgery < radiation | 0 | – | – | – |
| Control < Surgery | 0 | – | – | – |
| RD | ||||
| Radiation <control | 0 | – | – | – |
| Radiation <surgery | 0 | – | – | – |
| Surgery < control | 0 | – | – | – |
| Control < radiation | 7109 | 0.02 | CST, forceps major, IFOF, cingulum (cingulate gyrus), SLF, forceps minor, ATR, ILF, cingulum (hippocampus), SLF (temporal part) | 2.14 |
| 1229 | 0.02 | CST (L), ATR (L), CST (R) | 3.68 | |
| 699 | 0.03 | ATR | 3.53 | |
| Surgery < radiation | 0 | – | – | – |
| Control < surgery | 19,209 | < 0.01 | Forceps minor, SLF, forceps major, IFOF, ILF, CST, SLF (temporal part), cingulum (cingulate gyrus), ATR, UF, cingulum (hippocampus) | 1.85 |
| 5153 | 0.03 | ATR, CST, IFOF, ILF, UF, SLF, SLF (temporal part), cingulum (hippocampus) (R), forceps minor, cingulum (cingulate gyrus) (R) | 1.9 | |
| 3500 | 0.03 | CST (R), ATR (R), IFOF (R) | 2.27 | |
All structures are listed in order from greatest to least probability of being a member of the labelled regions within the atlas.
Abbreviations: ATR = anterior thalamic radiation; CST = corticospinal tract; IFOF = inferior fronto-occipital fasciculus; ILF = inferior longitudinal fasciculus; SLF = superior longitudinal fasciculus; UF = uncinate fasciculus.
Significant clusters (p < .05) containing <100 voxels were excluded.
a
WM structures: defined by the JHU White-Matter Tractography Atlas. Unless otherwise specified, structures listed refer to bilateral counterparts.