Plasma fibrinogen concentrations and clinical characteristics of patients with EOC. Fibrinogen concentrations were significantly associated with (A) tumor stage, (B) lymphatic metastasis, (C) venous metastasis, and (D) 5-year survival; (E) ROC curve of fibrinogen concentrations for discriminating between patients with advanced and early EOC. **, ##, ^^, △△, P<0.001 compared with stages “I–II” or “no”. EOC, epithelial ovarian cancer; ROC, receiver operating characteristic; AUC, area under the curve.