Table 3. Multivariable logistic regression analysis for occurrence of acute kidney injury in POD 0–3.
| Variables | Odds ratio (95% CI) | P value |
|---|---|---|
| Age, year | 1.00 (0.98, 1.03) | 0.962 |
| Preoperative comorbidities | ||
| ASA classification | ||
| 1 | 1 | 0.101 |
| 2 | 2.24 (1.05, 4.79) | 0.037 |
| ≥3 | 1.79 (0.62, 5.15) | 0.280 |
| eGFRa, mL/min/1.73 m2 | ||
| ≥90 | 1 | <0.001 |
| 60–90 | 0.60 (0.35, 1.02) | 0.058 |
| 30–60 | 3.62 (2.19, 5.98) | <0.001 |
| <30 or preoperative RRT | 1,096.1 (232.5, 5,166.8) | <0.001 |
| Hypertension | 0.92 (0.58, 1.46) | 0.708 |
| Ischemic heart disease | 1.18 (0.58, 2.40) | 0.642 |
| Diabetes mellitus | 2.27 (1.42, 3.63) | 0.001 |
| Anemia (hemoglobin <10 g/dL) | 1.75 (0.96, 3.19) | 0.068 |
| Operative characteristics | ||
| Surgery time, hour | 0.94 (0.57, 1.56) | 0.822 |
| Type of surgery | ||
| Total knee arthroplasty | 1 | |
| Total hip arthroplasty | 0.63 (0.29, 1.35) | 0.236 |
| Fluid input in POD 0, L | 0.82 (0.63, 1.06) | 0.127 |
| Transfusion of pRBC in POD 0 | 2.61 (1.26, 5.40) | 0.010 |
| Hydroxyethyl starch infused in POD 0 | 1.29 (0.66, 2.51) | 0.452 |
| Sedative uses for surgery | ||
| Midazolam, per 1 mg | 0.96 (0.79, 1.16) | 0.653 |
| Propofol, per 100 mg | 0.99 (0.94, 1.05) | 0.839 |
| Dexmedetomidine, per 100 μg | 0.95 (0.84, 1.09) | 0.461 |
All covariates of P<0.2 in univariable logistic regression analysis were included in multivariable logistic regression analysis. All covariates of P<0.2 in univariable regression analysis were included in multivariable regression model. Hosmer and Lemeshow stat: Chi-square: 6.935, P=0.544. All variance inflation factors in this multivariable model were <2.0. a, preoperative eGFR (mL/min/1.73 m2): 186 × (Creatinine)−1.154 × (Age)−0.203 × (0.742 if female). ASA, American society of anesthesiologists; eGFR, estimated glomerular filtration rate; RRT, renal replacement therapy; POD, postoperative day; POD, postoperative day.