Table 2.
Univariable and Multivariable Logistic Regression for analyzing the associated factors for developing bone metastases in ovarian cancer patients.
| Subject characteristics | Univariable | Multivariable | |||
|---|---|---|---|---|---|
| OR (95%CI) | P-value | OR (95%CI) | P-value | ||
| Age, in years | |||||
| 18-40 | Reference | 1.00 | Reference | 1.00 | |
| 41-64 | 1.11(0.70-1.77) | 0.66 | 0.40(0.16-1.01) | 0.05 | |
| ≥65 | 1.68(1.06-2.67) | 0.03 | 0.35(0.13-0.95) | 0.04 | |
| Marital status | |||||
| Married | Reference | 1.00 | Reference | 1.00 | |
| Unmarried | 1.37(1.10-1.69) | 0.01 | 0.92(0.51-1.65) | 0.77 | |
| Unknown | NA | NA | NA | NA | |
| T stage | |||||
| T1 | Reference | 1.00 | Reference | 1.00 | |
| T2 | 4.10(2.49-6.78) | <0.001 | 3.39(1.11-10.33) | 0.03 | |
| T3 | 3.04(1.95-4.74) | <0.001 | 1.78(0.59-5.39) | 0.31 | |
| Unknown | NA | NA | NA | NA | |
| N stage | |||||
| N0 | Reference | 1.00 | Reference | 1.00 | |
| N1 | 2.91(2.26-3.74) | <0.001 | 3.17(1.72-5.84) | <0.001 | |
| Unknown | NA | NA | NA | NA | |
| Differentiated Grade | |||||
| Ⅰ | Reference | 1.00 | Reference | 1.00 | |
| Ⅱ | 1.23(0.36-4.20) | 0.74 | 2.04(0.22-18.71) | 0.53 | |
| Ⅲ | 4.47(1.63-12.28) | 0.004 | 4.62(0.60-35.80) | 0.14 | |
| Ⅳ | 3.15(1.12-8.87) | 0.03 | 3.40(0.42-27.48) | 0.25 | |
| Unknown | NA | NA | NA | NA | |
| Histology | |||||
| Serous | Reference | 1.00 | Reference | 1.00 | |
| Non-serous | 2.24(1.74-2.88) | <0.001 | 3.05(1.63-5.72) | 0.001 | |
| Unknown | NA | NA | NA | NA | |
| CA-125 | |||||
| Normal | Reference | 1.00 | Reference | 1.00 | |
| Elevated | 1.91(1.13-3.22) | 0.02 | 1.33(0.49-3.58) | 0.58 | |
| Unknown | NA | NA | NA | NA | |
| Lung Met | |||||
| None | Reference | 1.00 | Reference | 1.00 | |
| Yes | 10.65(8.49-13.35) | <0.001 | 8.57(4.37-16.80) | <0.001 | |
| Unknown | NA | NA | NA | NA | |
| Liver Met | |||||
| None | Reference | 1.00 | Reference | 1.00 | |
| Yes | 9.86(7.90-12.32) | <0.001 | 4.95(2.50-9.82) | <0.001 | |
| Unknown | NA | NA | NA | NA | |
| Brain Met | |||||
| None | Reference | 1.00 | Reference | 1.00 | |
| Yes | 34.54(20.58-57.95) | <0.001 | 5.37(0.37-77.85) | 0.22 | |
| Unknown | NA | NA | NA | NA | |
Abbreviations: CA-125= cancer antigen 125; Met=Metastases; NA=Not available, all factors with Unknown data were removed in logistic regression model.