Table 3.
Univariate analysis with regard to OS in 468 patients with ESCC
| OS | DFS | |||||
|---|---|---|---|---|---|---|
| P value | HR | 95%CI | P value | HR | 95%CI | |
| Gender (female, male) | 0.589 | 1.088 | 0.800-1.479 | 0.496 | 1.113 | 0.818-1.513 |
| Age (≤60, >60) | 0.001* | 1.517 | 1.192-1.927 | 0.003* | 1.435 | 1.129-1.823 |
| Smoking (ever, never) | 0.033* | 1.297 | 1.021-1.647 | 0.025* | 1.313 | 1.034-1.668 |
| Drinking (yes, no) | 0.576 | 1.073 | 0.839-1.372 | 0.602 | 1.068 | 0.835-1.366 |
| Tumor size (cm) (≤3, >3) | 0.139 | 1.307 | 0.917-1.865 | 0.105 | 1.341 | 0.940-1.913 |
| Tumor location (upper/middle, lower) | 0.847 | 1.024 | 0.802-1.309 | 0.981 | 0.997 | 0.780-1.274 |
| Differentiation (well/moderate, poor) | 0.408 | 1.122 | 0.854-1.473 | 0.316 | 1.150 | 0.876-1.509 |
| T stage (T1/T2, T3/T4) | 0.004* | 1.525 | 1.143-2.036 | 0.005* | 1.515 | 1.135-2.023 |
| Lymph node metastasis (negative, positive) | <0.001* | 2.136 | 1.672-2.728 | <0.001* | 2.117 | 1.658-2.703 |
| TNM stage (I/II, III) | <0.001* | 2.304 | 1.805-2.941 | <0.001* | 2.310 | 1.811-2.948 |
| Operation time (min) (<200, ≥200) | 0.049* | 1.278 | 1.001-1.632 | 0.026* | 1.319 | 1.033-1.684 |
| Intraoperative blood loss (ml) (<200, ≥200) | 0.013* | 1.357 | 1.066-1.728 | 0.007* | 1.392 | 1.093-1.772 |
| SII (<479.72, ≥479.72) | 0.001* | 1.521 | 1.185-1.953 | <0.001* | 1.583 | 1.233-2.032 |
| NLR (<2.27, ≥2.27) | 0.033* | 1.325 | 1.022-1.718 | 0.035* | 1.323 | 1.020-1.715 |
| PLR (<117.05, ≥117.05) | 0.028* | 1.321 | 1.031-1.694 | 0.024* | 1.331 | 1.038-1.706 |
| MLR (<0.19, ≥0.19) | 0.104 | 1.225 | 0.959-1.566 | 0.094 | 1.234 | 0.965-1.576 |
*P less than 0.05 is significant.
CI = confidence interval; OS = overall survival; HR = hazard ratio;
SII = systemic immune-inflammation index; NLR = neutrophil-lymphocyte ratio; PLR = platelet-lymphocyte ratio; MLR = monocyte-lymphocyte ratio