Table 4.
Multivariate analysis with regard to OS in 468 patients with ESCC
| OS | DFS | |||||
|---|---|---|---|---|---|---|
| P value | HR | 95%CI | P value | HR | 95%CI | |
| Age (≤60, >60years) | <0.001* | 1.606 | 1.260-2.046 | 0.001* | 1.520 | 1.193-1.937 |
| Smoking (ever, never) | 0.163 | 1.191 | 0.932-1.523 | 0.176 | 1.183 | 0.928-1.508 |
| Differentiation (well/moderate, poor) | 0.522 | 1.094 | 0.831-1.441 | 0.444 | 1.113 | 0.846-1.464 |
| T stage (T1/T2, T3/T4) | 0.761 | 1.055 | 0.746-1.494 | 0.801 | 1.046 | 0.739-1.480 |
| Lymph node metastasis (negative, positive) | 0.221 | 1.295 | 0.856-1.957 | 0.276 | 1.258 | 0.832-1.901 |
| TNM stage (I/II, III) | <0.001* | 2.330 | 1.825-2.975 | <0.001* | 2.355 | 1.845-3.006 |
| Operation time (min) (<200, ≥200) | 0.030* | 1.314 | 1.027-1.682 | 0.012* | 1.372 | 1.307-2.162 |
| Intraoperative blood loss (ml) (<200, ≥200) | 0.231 | 1.166 | 0.907-1.498 | 0.180 | 1.186 | 0.924-2.105 |
| SII (<479.72, ≥479.72) | <0.001* | 1.604 | 1.247-2.063 | <0.001* | 1.681 | 1.307-2.162 |
| NLR (<2.27, ≥2.27) | 0.013* | 1.396 | 1.074-1.815 | 0.017* | 1.376 | 1.059-1.788 |
| PLR (<117.05, ≥117.05) | 0.013* | 1.370 | 1.067-1.758 | 0.009* | 1.398 | 1.089-1.794 |
| MLR (<0.19, ≥0.19) | 0.173 | 1. 188 | 0.927-1.522 | 0.118 | 0.820 | 0.640-1.052 |
*P less than 0.05 is significant.
CI = confidence interval; OS = overall survival; HR = hazard ratio;
SII = systemic immune-inflammation index; NLR = neutrophil-lymphocyte ratio; PLR = platelet-lymphocyte ratio; MLR = monocyte-lymphocyte ratio