Table 1.
Patients and disease characteristics in the gastric cancer and according to DLL4 status.
| Characteristic | N=336 (%) | DLL 4 (low) n=269 (80.1%) | DLL 4 (high) n=67 (19.9%) | p value |
|---|---|---|---|---|
| Age | ||||
| Median (range), years | 57 (28-77) | 56 (28-77) | 59 (33-77) | 0.104 |
| < 60 | 195 (58.0) | 162 (60.2) | 33 (49.3) | |
| >60 | 141 (42.0) | 107 (39.8) | 34 (50.7) | |
| Sex | ||||
| Male | 217 (64.6) | 172 (63.9) | 45 (67.2) | 0.622 |
| Female | 119 (35.4) | 97 (36.1) | 22 (32.8) | |
| Tumor Localization | 0.296 | |||
| Cardias | 17 (5.1) | 12 (4.5) | 5 (7.5) | |
| Body | 159 (47.3) | 133 (49.4) | 26 (38.7) | |
| Antrum | 125 (37.2) | 95 (35.3) | 30 (44.8) | |
| Whole/multiple | 35 (10.4) | 29 (10.8) | 6 (9.0) | |
| Histology | 0.042 | |||
| ADC,WD | 5 (1.5) | 2 (0.7) | 3 (4.5) | |
| ADC,MD | 109 (32.4) | 83 (30.9) | 26 (38.8) | |
| ADC,PD | 147 (43.8) | 119 (44.2) | 28 (41.8) | |
| Signet ring cell | 75 (22.3) | 65 (24.2) | 10 (14.9) | |
| Borrman classification | ||||
| 1 | 7 (2.1) | 4 (1.5) | 3 (4.5) | 0.308 |
| 2 | 98 (29.2) | 77 (28.6) | 21 (31.3) | |
| 3 | 193 (57.4) | 156 (58.0) | 37 (55.2) | |
| 4 | 38 (11.3) | 32 (11.9) | 6 (9.0) | |
| Lauren type | ||||
| Intestinal | 132 (39.2) | 92 (34.2) | 40 (59.7) | < 0.001 |
| Diffuse | 189 (56.3) | 164 (61.0) | 25 (37.3) | |
| Mixed | 15 (4.5) | 13 (4.8) | 2 (3.0) | |
| pT stage | ||||
| 1 | 8 (2.4) | 7 (2.6) | 1 (1.5) | 0.511 |
| 2a | 64 (19.0) | 54 (20.1) | 10 (14.9) | |
| 2b | 158 (47.0) | 120 (44.6) | 38 (56.7) | |
| 3 | 95(28.3) | 79 (29.4) | 16 (23.9) | |
| 4 | 11 (3.3) | 9 (3.3) | 2 (3.0) | |
| pN stage | ||||
| 0 | 13 (3.9) | 11 (4.1) | 2 (3.0) | 0.130 |
| 1 | 202 (60.1) | 165 (61.3) | 37 (55.2) | |
| 2 | 87 (25.9) | 71 (26.4) | 16 (23.9) | |
| 3 | 34 (10.1) | 22 (8.2) | 12 (17.9) | |
| Stage | 0.037 | |||
| II and IIIa | 271 (80.7) | 223 (82.9) | 48 (71.6) | |
| IIIb and IV | 65 (19.3) | 46 (17.1) | 19 (28.4) | |
| Cer-b status | 0.018 | |||
| negative | 281 (83.6) | 226(84.0) | 55(82.1) | |
| positive | 18 (5.4) | 9 (3.3) | 9 (13.4) | |
| unknown | 37 (11.0) | 34 (12.6) | 3 (4.5) | |
| Surgical resection | 0.929 | |||
| Subtotal | 199 (59.2) | 159 (59.1) | 40 (59.7) | |
| Total | 137 (40.8) | 110 (40.9) | 27 (40.3) | |
| Perineural invasion | ||||
| No | 177 (52.5) | 143(50.3) | 34 (50.7) | 0.743 |
| Yes | 159 (47.5) | 126 (47) | 33 (49.3) | |
| Lymphovascular invasion | ||||
| No | 106 (31.5) | 86 (32.0) | 20 (29.9) | 0.738 |
| Yes | 230 (68.5) | 183 (68.0) | 47 (70.1) |