Table 2.
Prognostic factors associated with DFS and OS as determined by univariate and multivariate analysis
| DFS | OS | ||||
|---|---|---|---|---|---|
| Variables | HR(95%CI) | p-value | Variables | HR(95%CI) | p-value |
| Univariate analysis | Univariate analysis | ||||
| DLL 4 negative vs. positive | 1.93(1.27-2.95) | 0.002 | DLL 4 negative vs. positive | 1.95(1.24-3.08) | 0.004 |
| *Histological differentiation | 1.72(1.10-2.67) | 0.016 | *Histological differentiation | 1.83(1.12-2.99) | 0.015 |
| Borrman (1,2 vs 3,4) | 1.85(1.33-2.56) | <0.001 | Borrman (1,2 vs 3,4) | 2.16(1.52-3.08) | <0.001 |
| Lauren intestinal vs. diffuse | 1.53(1.10-2.14) | 0.012 | Lauren intestinal vs. diffuse | 1.70(1.08-2.68) | 0.019 |
| pT 1,2 vs. pT 3,4 | 2.26(1.54-3.30) | <0.001 | pT 1,2 vs. pT 3,4 | 2.46(1.62-3.73) | <0.001 |
| pN 0,1 vs. pN 2,3 | 2.73(1.87-4.00) | <0.001 | pN 0,1 vs. pN 2,3 | 2.57(1.69-3.90) | <0.001 |
| Stage(II/IIIa versus IIIb/IV) | 3.82(2.58-5.65) | <0.001 | Stage(II/IIIa versus IIIb/IV) | 3.55(2.31-4.56) | <0.001 |
| Surgical resection TG vs STG | 1.70(1.16-2.47) | 0.007 | Surgical resection TG vs STG | 1.84(1.22-2.80) | 0.004 |
| Multivariate analysis | Multivariate analysis | ||||
| DLL 4 negative vs. positive | 1.80(1.14-2.86) | 0.012 | DLL 4 negative vs. positive | 2.07(1.23-3.46) | 0.006 |
| *Histological differentiation | 1.78(1.10-2.89) | 0.021 | Lauren intestinal vs. diffuse | 2.19(1.30-3.69) | 0.003 |
| Stage(II/IIIa versus IIIb/IV) | 3.95(2.56-6.11) | <0.001 | Stage(II/IIIa versus IIIb/IV) | 3.93(2.45-6.32) | <0.001 |