Table 2.
Japanese Society on Thrombosis and Hemostasis disseminated intravascular coagulation (DIC) scoring systems for infection
| Item | Score | ISTH overt‐DIC range |
|---|---|---|
| Platelet count (×109/L) | 3 | ≤50 |
| 2 | >50, ≤80 | |
| 1 | >80, ≤120 | |
| +1 | ≥30% decrease within 24 h | |
| FDP (μg/mL) | 3 | ≥40 |
| 2 | <40, ≥20 | |
| 1 | <20, ≥10 | |
| Prothrombin time ratio | 2 | ≥1.67 |
| 1 | >1.25, <1.67 | |
| Antithrombin (%) | 1 | ≤70 |
| TAT, SF, F1+2 | 1 | ≥2‐fold of normal upper limit |
| Liver failurea | −3 | Yes |
| Total score for DIC | ≥5 |
For institutions that measure only D‐dimer, 1 point will be added if D‐dimer increases ≥2‐fold the normal upper limit.
Corresponds to “a prothrombin time activity of ≤40% or an international normalized ratio value of ≥1.5 due to severe liver dysfunction seen within 8 weeks of onset of initial symptoms following liver impairment that develops in a normal liver or a liver that is thought to exhibit normal liver function” (acute liver failure) or “cirrhosis with a Child–Pugh classification of B or C (≥7 points)” (chronic liver failure).
F1+2, prothrombin fragment 1 + 2; FDP, fibrin/fibrinogen degradation product; ISTH, International Society on Thrombosis and Haemostasis; SF, soluble fibrin; TAT, thrombin–antithrombin complex.