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Knockdown (KD) of CCNC mimics miR-15b resisting sunitinib in ccRCC. A) miR-15 supplement decreasing levels of elements of CCNC signaling; B) Silencing CCNC using siRNA showing satisfactory effect; Cell cycle analysis showing restored G1 population following CCNC-KD in C) 786-O and D) ACHN cells; Apoptosis analysis showing restored apoptosis following CCNC-KD in C) 786-O and D) ACHN cells (**P < 0.01).
