Table 3.

Univariate and multivariate Cox regression analysis of overall survival in patients with colorectal cancer after tumor resection

	Univariate			Multivariate
Variable	HR(95% CI)	P value		HR(95% CI)	P value
Age (≤60 years vs. > 60 years)	1.154(0.806-1.653)	0.435
Sex (male vs. female)	0.939(0.650-1.357)	0.939
Primary tumor location (colon vs. rectum)	1.880(1.247-2.835)	0.003		1.022(0.665-1.571)	0.921
Tumor size (>5 cm vs. ≤5 cm)	0.700(0.465-1.055)	0.088
Primary tumor differentiation (poor vs. well to moderate)	1.549(0.996-2.408)	0.052
TNM stage (IV vs. II-III)	6.043(3.937-9.277)	<0.001		5.447(3.475-8.538)	<0.001
Preoperative CEA (>5 ng/ml vs. ≤ 5 ng/ml)	2.653(1.774-3.967)	<0.001		1.610(1.043-2.485)	0.032
Preoperative CA199 (>35 U/ml vs. ≤ 35 U/ml)	2.984(2.071-4.298)	<0.001		2.134(1.433-3.178)	<0.001
Adjuvant chemotherapy (yes vs. no)	0.838(0.570-1.232)	0.369
NDRG2 expression (low vs. high)	1.550(1.077-2.232)	0.018		1.499(1.037-2.165)	0.031

Abbreviations: HRs: hazard ratios, CI: confidence interval, TNM stage: tumor-node-metastasis classification, CEA: carcinoembryonic antigen, CA19-9: carbohydrate antigen 19-9