Table 2. Clinical studies in SCAD currently registered at www.clinicaltrials.gov.
| Trial name | Primary Site | Patient number | Study design | Size | Primary outcomes | Secondary outcomes |
Follow-up | Completion date |
|---|---|---|---|---|---|---|---|---|
| Angiographic and Psychosocial Evaluation of Peripartum vs. Non: SCAD (SCAD) | Stanford University, California, US | 600 | Prospective observational | Multi-centre | Major adverse cardiac events | Outcomes of depression, anxiety, stress and PTSD | 6 months | Aug-19 |
| Spanish Registry on Spontaneous Coronary Artery Dissection (SR-SCAD) | Spain | 300 | Prospective observational | Multi-centre | predictors of adverse events | Predictors of recurrence | 3 years | Jan-20 |
| The Study of the Prevalence of Fibromuscular Dysplasia in Patients With Haematoma or Spontaneous Coronary Artery Dissection (DISCO) | University Hospital, Clermont-Ferrand, France | 200 | Prospective observational | Single centre | Incidence of SCAD in ACS | Genetic, environmental hormonal factors, prevalence of FMD | 1 year | May-20 |
| Canadian SCAD Study | Vancouver General Hospital | 750 | Prospective observational | Multi-centre | Composite in-hospital outcome | Composite follow-up outcome | 3 years | Dec-20 |
| Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD) | Mayo Clinic, Minnesota, USA | 1,000 | Prospective observational | Single centre | Genomic and plasma biobank of patients with SCAD | Identify inherited and new mutations that underlie SCAD | N/A | Dec-20 |
| Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD (SAFER-SCAD) | Vancouver General Hospital, Vancouver, Canada | 40 | Interventional | Single centre | Frequency of angina | ACS or hospitalisation | 16 weeks/52 weeks | Jun-21 |
| The “Virtual” Multicenter Spontaneous Coronary Artery Dissection (SCAD) Registry (SCAD) | Mayo Clinic, Minnesota, USA | 900 | Observational | Single centre | Descriptive data (presenting characteristics, treatments and outcomes) | Physical and mental health updates | 2 years | Dec-25 |
| Spontaneous Coronary Artery Dissection anaLysIs of the Brazilian Updated Registry (SCALIBUR) | Hospital Israelita, Sao Paul, Brazil | 250 | Cross-sectional | Single centre | Long-term clinical outcomes | Multimodality intravascular imaging findings | 10 years | Dec-27 |