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. 2019 Jun 7;19(11):2595. doi: 10.3390/s19112595

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme of the four studied sensing configurations. (A) The bare-TFBGs with adsorbed antibodies on the silica surface. (B) The sputter deposition under vacuum and the covalent bonding of anti-CK17 antibodies on the gold film. (C) The electroless deposition of gold and the covalent bonding of anti-CK17 antibodies on the agglomerated Au particles. (D) A hybrid-coating coupling a deposition of 4 nm Au by sputter-coater followed by an ELP deposition, which is functionalized using covalent bonding of anti-CK17 antibodies.