Table 2.

Advantages of propensity score methodology

Advantages	Remarks
Addressing “curse of dimensionality” when EPV < 10	Traditional multivariable regression models yield similar results if EPV ≥ 10
Recognition of subjects with absolute indications (or contraindications) of an intervention	Exclusion of areas of non-overlap of the PS distribution between exposed and unexposed groups to ensure comparability
Identification of PS interaction with treatment	Variation of effectiveness of an intervention according to indications (PS) may only be identified via stratified analysis by PS

EPV: Events per variable; PS: Propensity score.