Table 6.
Examples of studies on colorectal cancer research by utilization of large healthcare datasets
|
Colorectal cancer | |||||
| Country/Region | Database | Area of research | Sample size | Design, statistical methods and 3V | Application |
| Hong Kong, China | Clinical Data Analysis and Reporting System (CDARS) | CRC | 197902 | Territory-wide retrospective cohort study | Epidemiology, characteristics, risk factors and prognosis of postcolonoscopy Colorectal cancer in Asians |
| Cheung et al[101], 2019 | |||||
| Volume, Velocity and Variety | |||||
| CRC | 187897 | Territory-wide retrospective cohort study | Association between statins and CRC | ||
| Cheung et al[69], 2019 | |||||
| PS matching | |||||
| Volume, Velocity and Variety | |||||
| United States | Nurses’ Health Study II (NHSII) | CRC | 134763 | Prospective cohort study | Association between DM and CRC |
| Ma et al[74], 2018 | |||||
| Volume and Variety | |||||
| Health Professionals Follow-up Study (HPFS) | |||||
| Nurses’ Health Study (NHS) | CRC | 1660 | Prospective cohort study | Effect of calcium intake, coffee and fibre on survival after CRC diagnosis | |
| Yang et al[78], 2018 | |||||
| 1599 | |||||
| Volume and Variety | |||||
| Health Professionals Follow-up Study (HPFS) | Hu et al[77], 2018 | ||||
| 1575 | |||||
| Song et al[79], 2018 | |||||
| Nurses’ Health Study (NHS) | CRC | 141143 | Prospective cohort study | Risk factors of serrated polyps and conventional adenomas | |
| He et al[76], 2018 | |||||
| Nurses’ Health Study II (NHSII) | |||||
| de Jong et al[80], 2006 | |||||
| Volume and Variety | |||||
| Health Professionals Follow-up Study (HPFS) | |||||
| Nurses’ Health Study II (NHSII) | CRC | 85256 | Prospective cohort study | Association between obesity and CRC | |
| Liu et al[75], 2018 | |||||
| Volume and Variety | |||||
| Netherlands | Dutch Lynch syndrome Registry | Various cancers including | 2788 | Retrospective cohort study | Decrease in CRC-related mortality in Lynch syndrome families by surveillance |
| Volume, Velocity and Variety | |||||
| CRC | |||||
| Netherlands, Germany, Finland | Dutch Lynch syndrome Registry | CRC | 2747 patients with 16327 colonoscopies | Retrospective cohort study | Surveillance interval on CRC incidence and stage |
| Engel et al[81], 2018 | |||||
| Volume, Velocity and Variety | |||||
| German HNPCC Consortium | |||||
| Finland | |||||
This list is not exhaustive, but serves to provide a few distinct examples of how Big Data analysis can generate high-quality research outputs in the field of gastroenterology and hepatology. 3V: Volume/velocity/variety; CRC: Colorectal cancer; DM: Diabetes mellitus.