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. 2019 May 9;44:311–321. doi: 10.1016/j.ebiom.2019.05.003

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© 2019 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — miR-567 suppresses the PI3K/AKT-c-Myc pathway via targeting PIK3AP1. CCK-8 assay (A), colony formation assay (B), FACS assays (C) and EdU incorporation assays (D) showed miR-567-inhibited cell proliferation was counteracted after administration of PIK3AP1, Student's t-test, mean ± SD, *P < .05; **P < .01; ***P < .001. (E) The miR-567-induced downregulation of relevant proteins in cell cycle marker (CDK4, CDK6 and CyclinD1) as well as upregulation of pro-apoptosis proteins and cell cycle marker p21 were abrogated after administration of PIK3AP1 in MGC803 and BGC823 cells. (F) PIK3AP1 overexpression reversed miR-567-induced cell sensitivity to 5-FU compared to control cells. Student's t-test, mean ± SD, ***P < .001.