Table 4.
Sphingolipids (SP) in supernatant fluid (SF) and nanoparticle (NP) of late-onset Alzheimer’s disease (LOAD) and other dementia (OD).
| SP Classes in SF | LOAD (ng/mL) | OD (ng/mL) | 1 Difference (% LOAD) |
| SM | 1888.2 ± 138.2 | 1892.1 ± 400.1 | 2.1 |
| CM | 60.0 ± 6.9 | 73.2 ± 20.9 | 22.2 |
| dhCM | 179.2 ± 18.9 | 186.3 ± 63.7 | 4.0 |
| CM/SM | 0.0309 ± 0.0022 | 0.0369 ± 0.0041 | 19.4 |
| SP Classes in NP | LOAD (ng/mL) | OD (ng/mL) | % LOAD |
| SM | 95.2 ± 8.1 | 110.7 ± 20.6 | 16.3 |
| CM | 5.9 ± 0.6 | 6.5 ± 0.4 | 9.4 * |
| dhCM | 53.9 ± 3.0 | 55.6 ± 5.7 | 3.2 |
| CM/SM | 0.07 ± 0.01 | 0.08 ± 0.01 | 2.7 |
These data are the mean ± SEM, ng/mL. The p values compare sphingolipids in LOAD versus OD and * denotes p < 0.05. 1 Difference of means as the percentage of LOAD = (OD–LOAD)/LOAD × 100. SM: sphingomyelin; CM: ceramide; dhCM: dihydroceramide; CM/SM: ceramide to sphingomyelin ratio.