Table 2.
Parameter | F1-LD-F1 Model | Relative Treatment Effects | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
F | p-value | Time | Interaction Effects | |||||||||
Oral FeNO (ppb) | Treat | 1.15 (1.00, ∞) | 1.000 | n.s | Exercise | 0.42 | T0 | 0.54 | Exercise × T0 | 0.55 | Control × T0 | 0.52 |
Time | 4.39 (1.63, ∞) | 0.055 | Control | 0.53 | T1 | 0.39 | Exercise × T1 | 0.29 | Control × T1 | 0.49 | ||
Treat × Time | 3.17 (1.63, ∞) | 0.261 | n.s | T2 | 0.50 | Exercise × T2 | 0.41 | Control × T2 | 0.58 | |||
Treat × T1 | 10.23 (1.0, ∞) | 0.008 | ** | |||||||||
Nasal FeNO (ppb) | Treat | 0.37 (1.00, ∞) | 1.000 | n.s | Exercise | 0.46 | T0 | 0.52 | Exercise × T0 | 0.55 | Control × T0 | 0.48 |
Time | 0.65 (1.83, ∞) | 0.509 | n.s | Control | 0.52 | T1 | 0.44 | Exercise × T1 | 0.40 | Control × T1 | 0.47 | |
Treat × Time | 0.99 (1.83, ∞) | 0.733 | n.s | T2 | 0.51 | Exercise × T2 | 0.44 | Control × T2 | 0.59 | |||
Nasal Eosinophil Count (%) | Treat | 0.08 (1.00, ∞) | 1.000 | n.s | Exercise | 0.51 | T0 | 0.50 | Exercise × T0 | 0.57 | Control × T0 | 0.42 |
Time | 2.40 (1.98, ∞) | 0.183 | n.s | Control | 0.49 | T1 | 0.46 | Exercise × T1 | 0.45 | Control × T1 | 0.47 | |
Treat × Time | 3.90 (1.98, ∞) | 0.021 | * | T2 | 0.55 | Exercise × T2 | 0.52 | Control × T2 | 0.58 | |||
Mucociliary Clearance Time (min) | Treat | 0.50 (1.00, ∞) | 0.754 | n.s | Exercise | 0.47 | T0 | 0.52 | Exercise × T0 | 0.50 | Control × T0 | 0.55 |
Time | 3.64 (1.8,1 ∞) | 0.061 | n.s | Control | 0.52 | T1 | 0.44 | Exercise × T1 | 0.38 | Control × T1 | 0.50 | |
Treat × Time | 1.88 (1.81, ∞) | 0.470 | n.s | T2 | 0.53 | Exercise × T2 | 0.53 | Control × T2 | 0.52 | |||
FVC (%) | Treat | 0.06 (1.00, ∞) | 1.000 | n.s | Exercise | 0.49 | T0 | 0.50 | Exercise × T0 | 0.47 | Control × T0 | 0.52 |
Time | 0,65 (1.81, ∞) | 1.000 | n.s | Control | 0.51 | T1 | 0.49 | Exercise × T1 | 0.48 | Control × T1 | 0.51 | |
Treat × Time | 1,92 (1.81, ∞) | 0.303 | n.s | T2 | 0.51 | Exercise × T2 | 0.51 | Control × T2 | 0.50 | |||
FEV1 | Treat | 0.89 (1.00, ∞) | 0.689 | n.s | Exercise | 0.45 | T0 | 0.49 | Exercise × T0 | 0.44 | Control × T0 | 0.54 |
Time | 1.58 (1.81, ∞) | 0.416 | n.s | Control | 0.54 | T1 | 0.51 | Exercise × T1 | 0.47 | Control × T1 | 0.55 | |
Treat × Time | 0.49 (1.81, ∞) | 1.000 | n.s | T2 | 0.48 | Exercise × T2 | 0.45 | Control × T2 | 0.52 | |||
FEV1/FVC (%) | Treat | 1.71 (1.00, ∞) | 0.585 | n.s | Exercise | 0.43 | T0 | 0.49 | Exercise × T0 | 0.43 | Control × T0 | 0.55 |
Time | 4.10 (1.85, ∞) | 0.076 | Control | 0.55 | T1 | 0.52 | Exercise × T1 | 0.47 | Control × T1 | 0.56 | ||
Treat × Time | 2.61 (1.85, ∞) | 0.313 | n.s | T2 | 0.47 | Exercise × T2 | 0.40 | Control × T2 | 0.55 | |||
PEF (%) | Treat | 0.05 (1.00, ∞) | 1.000 | n.s | Exercise | 0.49 | T0 | 0.46 | Exercise × T0 | 0.48 | Control × T0 | 0.45 |
Time | 2.70 (1.98, ∞) | 0.068 | Control | 0.51 | T1 | 0.52 | Exercise × T1 | 0.48 | Control × T1 | 0.56 | ||
Treat × Time | 2.59 (1.88, ∞) | 0.302 | n.s | T2 | 0.51 | Exercise × T2 | 0.51 | Control × T2 | 0.52 | |||
MEF 25%-75% | Treat | 1.94 (1.00, ∞) | 0.328 | n.s | Exercise | 0.43 | T0 | 0.49 | Exercise × T0 | 0.41 | Control × T0 | 0.56 |
Time | 2.73 (1.76, ∞) | 0.145 | n.s | Control | 0.56 | T1 | 0.52 | Exercise × T1 | 0.47 | Control × T1 | 0.56 | |
Treat × Time | 2.00 (1.76, ∞) | 0.284 | n.s | T2 | 0.48 | Exercise × T2 | 0.41 | Control × T2 | 0.55 | |||
WBC (10³/µL) | Treat | 9.16 (1.00, ∞) | 0.005 | ** | Exercise | 0.62 | T0 | 0.52 | Exercise × T0 | 0.67 | Control × T0 | 0.36 |
Time | 0.27 (1.98, ∞) | 0.758 | n.s | Control | 0.40 | T1 | 0.49 | Exercise × T1 | 0.52 | Control × T1 | 0.47 | |
Treat × Time | 6.31 (1.98, ∞) | 0.002 | ** | T2 | 0.52 | Exercise × T2 | 0.66 | Control × T2 | 0.38 | |||
RBC (106/µL) | Treat | 0.24 (1.00, ∞) | 0.622 | n.s | Exercise | 0.52 | T0 | 0.53 | Exercise × T0 | 0.54 | Control × T0 | 0.53 |
Time | 1.35 (1.93, ∞) | 0.520 | n.s | Control | 0.48 | T1 | 0.49 | Exercise × T1 | 0.52 | Control × T1 | 0.45 | |
Treat × Time | 0.40 (1.93, ∞) | 1.000 | n.s | T2 | 0.49 | Exercise × T2 | 0.51 | Control × T2 | 0.46 | |||
Blood Neutrophil count (%) | Treat | 0.65 (1.00, ∞) | 0.419 | n.s | Exercise | 0.54 | T0 | 0.51 | Exercise × T0 | 0.59 | Control × T0 | 0.44 |
Time | 0.16 (1.57, ∞) | 0.798 | n.s | Control | 0.47 | T1 | 0.50 | Exercise × T1 | 0.52 | Control × T1 | 0.48 | |
Treat × Time | 2.25 (1.57, ∞) | 0.235 | n.s | T2 | 0.50 | Exercise × T2 | 0.51 | Control × T2 | 0.49 | |||
Blood Eosinophil count (%) | Treat | 0.01 (1.00, ∞) | 0.907 | n.s | Exercise | 0.49 | T0 | 0.50 | Exercise × T0 | 0.51 | Control × T0 | 0.49 |
Time | 0.18 (1.62, ∞) | 0.787 | n.s | Control | 0.50 | T1 | 0.49 | Exercise × T1 | 0.50 | Control × T1 | 0.48 | |
Treat × Time | 1.21 (1.62, ∞) | 0.292 | n.s | T2 | 0.51 | Exercise × T2 | 0.48 | Control × T2 | 0.54 |
F1-LD-F1 model with time and treatment (treat, exercise or control) and the interaction of treatment and time (treat × time); T0, T1 and T2 time points T0 = day 0, T1 = day 10, T2 = day 60; ** <0.01; * <0.005; <0.1; n.s. not significant. Abbreviations: PEF, peak expiratory flow; MEF 25%–75%, mid-expiratory flow at 25%–75% of the FVC; WBC, white blood cell count; RBC, red blood cell count.