. 2019 Jun 8;16(11):2040. doi: 10.3390/ijerph16112040

Table 2.

Results from the F1-LD-F1 model for FeNO, nasal eosinophilic count, mucociliary clearance time, spirometry and differential blood count.

Parameter	F1-LD-F1 Model				Relative Treatment Effects
Parameter		F	p-value				Time		Interaction Effects
Oral FeNO (ppb)	Treat	1.15 (1.00, ∞)	1.000	n.s	Exercise	0.42	T0	0.54	Exercise × T0	0.55	Control × T0	0.52
	Time	4.39 (1.63, ∞)	0.055		Control	0.53	T1	0.39	Exercise × T1	0.29	Control × T1	0.49
	Treat × Time	3.17 (1.63, ∞)	0.261	n.s			T2	0.50	Exercise × T2	0.41	Control × T2	0.58
	Treat × T1	10.23 (1.0, ∞)	0.008	**
Nasal FeNO (ppb)	Treat	0.37 (1.00, ∞)	1.000	n.s	Exercise	0.46	T0	0.52	Exercise × T0	0.55	Control × T0	0.48
	Time	0.65 (1.83, ∞)	0.509	n.s	Control	0.52	T1	0.44	Exercise × T1	0.40	Control × T1	0.47
	Treat × Time	0.99 (1.83, ∞)	0.733	n.s			T2	0.51	Exercise × T2	0.44	Control × T2	0.59
Nasal Eosinophil Count (%)	Treat	0.08 (1.00, ∞)	1.000	n.s	Exercise	0.51	T0	0.50	Exercise × T0	0.57	Control × T0	0.42
	Time	2.40 (1.98, ∞)	0.183	n.s	Control	0.49	T1	0.46	Exercise × T1	0.45	Control × T1	0.47
	Treat × Time	3.90 (1.98, ∞)	0.021	*			T2	0.55	Exercise × T2	0.52	Control × T2	0.58
Mucociliary Clearance Time (min)	Treat	0.50 (1.00, ∞)	0.754	n.s	Exercise	0.47	T0	0.52	Exercise × T0	0.50	Control × T0	0.55
	Time	3.64 (1.8,1 ∞)	0.061	n.s	Control	0.52	T1	0.44	Exercise × T1	0.38	Control × T1	0.50
	Treat × Time	1.88 (1.81, ∞)	0.470	n.s			T2	0.53	Exercise × T2	0.53	Control × T2	0.52
FVC (%)	Treat	0.06 (1.00, ∞)	1.000	n.s	Exercise	0.49	T0	0.50	Exercise × T0	0.47	Control × T0	0.52
	Time	0,65 (1.81, ∞)	1.000	n.s	Control	0.51	T1	0.49	Exercise × T1	0.48	Control × T1	0.51
	Treat × Time	1,92 (1.81, ∞)	0.303	n.s			T2	0.51	Exercise × T2	0.51	Control × T2	0.50
FEV₁	Treat	0.89 (1.00, ∞)	0.689	n.s	Exercise	0.45	T0	0.49	Exercise × T0	0.44	Control × T0	0.54
	Time	1.58 (1.81, ∞)	0.416	n.s	Control	0.54	T1	0.51	Exercise × T1	0.47	Control × T1	0.55
	Treat × Time	0.49 (1.81, ∞)	1.000	n.s			T2	0.48	Exercise × T2	0.45	Control × T2	0.52
FEV₁/FVC (%)	Treat	1.71 (1.00, ∞)	0.585	n.s	Exercise	0.43	T0	0.49	Exercise × T0	0.43	Control × T0	0.55
	Time	4.10 (1.85, ∞)	0.076		Control	0.55	T1	0.52	Exercise × T1	0.47	Control × T1	0.56
	Treat × Time	2.61 (1.85, ∞)	0.313	n.s			T2	0.47	Exercise × T2	0.40	Control × T2	0.55
PEF (%)	Treat	0.05 (1.00, ∞)	1.000	n.s	Exercise	0.49	T0	0.46	Exercise × T0	0.48	Control × T0	0.45
	Time	2.70 (1.98, ∞)	0.068		Control	0.51	T1	0.52	Exercise × T1	0.48	Control × T1	0.56
	Treat × Time	2.59 (1.88, ∞)	0.302	n.s			T2	0.51	Exercise × T2	0.51	Control × T2	0.52
MEF _25%-75%	Treat	1.94 (1.00, ∞)	0.328	n.s	Exercise	0.43	T0	0.49	Exercise × T0	0.41	Control × T0	0.56
	Time	2.73 (1.76, ∞)	0.145	n.s	Control	0.56	T1	0.52	Exercise × T1	0.47	Control × T1	0.56
	Treat × Time	2.00 (1.76, ∞)	0.284	n.s			T2	0.48	Exercise × T2	0.41	Control × T2	0.55
WBC (10³/µL)	Treat	9.16 (1.00, ∞)	0.005	**	Exercise	0.62	T0	0.52	Exercise × T0	0.67	Control × T0	0.36
	Time	0.27 (1.98, ∞)	0.758	n.s	Control	0.40	T1	0.49	Exercise × T1	0.52	Control × T1	0.47
	Treat × Time	6.31 (1.98, ∞)	0.002	**			T2	0.52	Exercise × T2	0.66	Control × T2	0.38
RBC (10⁶/µL)	Treat	0.24 (1.00, ∞)	0.622	n.s	Exercise	0.52	T0	0.53	Exercise × T0	0.54	Control × T0	0.53
	Time	1.35 (1.93, ∞)	0.520	n.s	Control	0.48	T1	0.49	Exercise × T1	0.52	Control × T1	0.45
	Treat × Time	0.40 (1.93, ∞)	1.000	n.s			T2	0.49	Exercise × T2	0.51	Control × T2	0.46
Blood Neutrophil count (%)	Treat	0.65 (1.00, ∞)	0.419	n.s	Exercise	0.54	T0	0.51	Exercise × T0	0.59	Control × T0	0.44
	Time	0.16 (1.57, ∞)	0.798	n.s	Control	0.47	T1	0.50	Exercise × T1	0.52	Control × T1	0.48
	Treat × Time	2.25 (1.57, ∞)	0.235	n.s			T2	0.50	Exercise × T2	0.51	Control × T2	0.49
Blood Eosinophil count (%)	Treat	0.01 (1.00, ∞)	0.907	n.s	Exercise	0.49	T0	0.50	Exercise × T0	0.51	Control × T0	0.49
	Time	0.18 (1.62, ∞)	0.787	n.s	Control	0.50	T1	0.49	Exercise × T1	0.50	Control × T1	0.48
	Treat × Time	1.21 (1.62, ∞)	0.292	n.s			T2	0.51	Exercise × T2	0.48	Control × T2	0.54

F1-LD-F1 model with time and treatment (treat, exercise or control) and the interaction of treatment and time (treat × time); T0, T1 and T2 time points T0 = day 0, T1 = day 10, T2 = day 60; ** <0.01; * <0.005; <0.1; n.s. not significant. Abbreviations: PEF, peak expiratory flow; MEF _25%–75%, mid-expiratory flow at 25%–75% of the FVC; WBC, white blood cell count; RBC, red blood cell count.