Figure 2.

Zidebactam (ZID) sensitizes New Delhi metallo-β-lactamase (NDM)-1–producing Klebsiella pneumoniae (KP) to killing by LL-37. A, As seen with avibactam (AVI; 4 mg/L), ZID (4 mg/L), a diazabicyclooctane β-lactamase inhibitor (BLI) without a β-lactam ring, synergizes with LL-37 (8 μM) to kill NDM-1–producing KP in a dose-dependent fashion (B and D), whereas TAZ (20 mg/L), a BLI with a 4-membered β-lactam ring that is hydrolyzed by β-lactamases, does not demonstrate synergy (C). CFU, colony-forming units. ****P < .0001, by Kruskal-Wallis 1-way analysis of variance.