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. 2019 Mar 29;220(3):484–493. doi: 10.1093/infdis/jiz128

Table 1.

Minimum Inhibitory Concentration (MICs) of Various Antibiotics Against New Delhi Metallo-β-Lactamase (NDM)-1–Producing Klebsiella pneumoniae, by Media

Antibiotic MIC, mg/L
CA-MHBa 5% LB–RPMIb
Avibactam 128 64
Ceftazidime >64 >64
Ceftazidime-avibactam (Avycaz) 64 64
Meropenem 128 512
Meropenem-vaborbactam (Vabomere) 32 256
Tazobactam >64 >64
Ceftolozane-tazobactam >64 >64
Aztreonam 512 32
LL-37 64 64

K. pneumoniae clinical isolate CDC 1100192, obtained from a sputum specimen, was used in this study.

aCation-adjusted Müller-Hinton broth (CA-MHB).

b5% Luria broth in Roswell Park Memorial Institute (RPMI) 1640 tissue culture medium.