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. 2019 May 10;44:361–374. doi: 10.1016/j.ebiom.2019.05.008

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — LTA4H and BLT1 are overexpressed in human colon adenocarcinoma tissues and colitis and are associated with CRC patient survival probability. (a) LTA4H levels in human colon tissue were analyzed by immunohistochemistry and the density score from each sample was determined (right panel). Representative cases are shown (left panels). The asterisk (*, ***) indicates a significant (p < .05, p < .001, respectively) increase in LTA4H expression in colon adenocarcinoma tissue compared with normal tissue (scale bar, 100 μm). (b) LTB4 concentration in human serum was detected by ELISA assay. The asterisks (**) indicate a significant (p < .01) difference in CRC patients compared with normal adult subjects. (c) LTA4H levels in human colitis were analyzed by immunohistochemistry. The asterisks (***) indicate a significant (p < .001) increase in LTA4H expression in colitis tissue compared with normal tissue (scale bar, 100 μm). (d) Kaplan-Meier survival curves showed the life span of CRC patients with LTA4H high expression (n = 32) or LTA4H low expression (n = 31). (e) BLT1 levels in human colon tissue were analyzed by immunohistochemistry. The asterisks (**, ***) indicate a significant (p < .01, p < .001, respectively) increase in BLT1 expression in colon adenocarcinoma tissue compared with normal tissue (scale bar, 100 μm). (f) BLT1 levels in human colitis were analyzed by immunohistochemistry. The asterisks (***) indicate a significant (p < .001) increase in BLT1 expression in colitis tissue compared with normal tissue (scale bar, 100 μm). (g) Kaplan-Meier survival curves relative to BLT1 expression were analyzed for CRC patients.