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. 2019 Jun 23;26:101260. doi: 10.1016/j.redox.2019.101260

Fig. 6.

Fig. 6

BAM15 Uncoupling Reverses Detrimental Effects of Glutamine in Slc4a11 KO. (A) %AnV+ WT and KO MCEC incubated in assay media +0.5 mM glutamine, and ±1 μM BAM15 for 24 h, n = 3, *p < 0.05 ± BAM15. (B) BAM15 uncoupling reduces Gln-dependent MitoROS. MCEC WT and KO were incubated in assay media +0.5 mM glutamine, and ±1 μM BAM15 for 24 h, n = 3, *p < 0.05 ± BAM15. (C) %TMRE+ and (D) Geometric mean of TMRE+ population of WT and KO MCEC incubated in assay media ±0.5 mM Gln, and ±1 μM BAM15 for 24 h then stained with TMRE. (E) Restoration of [ATP] in KO MCEC by BAM15 in 0.5 mM Gln, n = 3, *p < 0.05 vs no BAM15 for same genotype. (F) Basal Oxygen Consumption in KO rescued by BAM15 uncoupling, n = 3, *p < 0.05 ± BAM15.